期刊
CELLULAR IMMUNOLOGY
卷 250, 期 1-2, 页码 91-104出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2008.01.009
关键词
siglec; non-human primate; SIV infection; monocytes; hematopoietic cell lineages
资金
- NCRR NIH HHS [P51 RR000165-370005, P51 RR000165, RR-00165] Funding Source: Medline
- NIAID NIH HHS [R01 AI078773, R01 AI027057-17, R01 AI 27057, R01 AI027057, R01 AI027057-13A2] Funding Source: Medline
- Wellcome Trust [081882] Funding Source: Medline
The expression of the Siglec family of molecules by hematopoietic cells from uninfected and SIV infected disease susceptible rhesus macaques (RM) and SIV infected disease resistant sooty mangabeys (SM) and for comparison humans was carried out. The predominant cell lineage in all three species expressing Siglec's was monocytes. The major finding by both a cross sectional and a prospective SIV infection study showed that, whereas monocytes from RM show marked increase in each Siglec constitutively expressed, monocytes from SM showed marked decreases in Siglec-1 expression. While monocytes from all three species constitutively expressed Siglec-3, human monocytes in addition expressed Siglec-5 and -9 and to a lower density 7, monocytes from RM expressed Siglec-7 and those from SM expressed Siglec-1. Monocytes from all three species, however, expressed mRNA for Siglec-1, -5, -7 and -9. The reasons for the failure to detect these molecules at the protein level and the mechanisms for such distinct effects of SIV infection on Siglec expression are discussed. (c) 2008 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据