期刊
NEUROBIOLOGY OF AGING
卷 28, 期 11, 页码 1718-1722出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2006.07.010
关键词
frontotemporal lobar degeneration; hippocampal sclerosis; motor neuron disease; ubiquitin
资金
- NIA NIH HHS [P50-AG16574, P01-AG17216, P01-AG03949, P01-AG14449] Funding Source: Medline
- NICHD NIH HHS [K12-HD49078] Funding Source: Medline
- NINDS NIH HHS [P50-NS40256] Funding Source: Medline
Tau-negative frontotemporal lobar degeneration (FTLD) can be divided into those with motor neuron disease (FTLD-MND), and those without MND, but with ubiquitin-immunoreactive neuronal inclusions (FTLD-U). Some authors group FTLD-U and FTLD-MND together as tau-negative FTLD, but others separate them on the basis of clinical, pathologic and imaging differences. In 103 cases of pathologically confirmed, tau-negative FTLD (FTLD-MND and FTLD-U), we assessed the frequency of hippocampal sclerosis defined as neuronal loss in the subicular or CA I regions of the hippocampus. The subjects in the FTLD-U group were older at death and had longer disease duration. After adjusting for age at death and disease duration, we found a significant difference in the frequency of hippocampal sclerosis in the FTLD-U group (79%) compared to FTLD-MND group (26%) (p = 0.02). The difference in frequency of HpScl in FTLD-U compared to FTLD-MND is further evidence that they are separate clinicopathologic entities. (c) 2006 Elsevier Inc. All rights reserved.
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