期刊
NATURE REVIEWS CANCER
卷 7, 期 11, 页码 861-869出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2248
关键词
-
类别
资金
- Medical Research Council [G0300662B, G0500897] Funding Source: researchfish
- Medical Research Council [G0500897] Funding Source: Medline
- MRC [G0500897] Funding Source: UKRI
DNA damage responses (DDR) encompass DNA repair and signal transduction pathways that effect cell cycle checkpoint arrest and/or apoptosis. How DDR pathways respond to low levels of DNA damage, including low doses of ionizing radiation, is crucial for assessing environmental cancer risk. It has been assumed that damage-induced cell cycle checkpoints respond to a single double strand break (DSB) but the G2/M checkpoint, which prevents entry into mitosis, has recently been shown to have a defined threshold of 10-20 DSBs. Here, we consider the impact of a negligent G2/M checkpoint on genomic stability and cancer risk.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据