期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 64, 期 22, 页码 2887-2899出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-007-7310-9
关键词
nitrite reductase; amine oxidase; superoxide dismutase; dopamine monooxygenase; peptidyl; amidating enzyme
Type-2 Cu sites are found in all the major branches of life and are often involved in the catalysis of oxygen species. Four type-2 Cu protein families are selected as model systems for review: amine oxidases, Cu monooxygenases, nitrite reductase/multicopper oxidase, and CuZn superoxide dismutase. For each model protein, the availability of multiple crystal structures and detailed enzymological studies provides a detailed molecular view of the type-2 Cu site and delineation of the mechanistic role of the Cu in biological function. Comparison of these model proteins leads to the identification of common properties of the Cu sites and insight into the evolution of the trinuclear active site found in multicopper oxidases.
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