期刊
MOLECULAR PHARMACEUTICS
卷 4, 期 6, 页码 895-910出版社
AMER CHEMICAL SOC
DOI: 10.1021/mp060133c
关键词
nuclear receptors; conjugation; hydroxylation; detoxification; drug-induced liver disease; acetaminophen; cholestasis
Drug-induced liver injury (DILI) is a rare condition. This review presents a clinical update on the incidence and prevalence of DILI, cellular targets and histopathological features of liver injury, and basic diagnostic approaches. At present, with the exception of acetaminophen poisoning where timely administered N-acetylcysteine serves as the antidote, treatment usually is supportive. Since most biotransformation processes in the liver are under the control of nuclear receptors (NR), treatment modalities aiming to stimulate or inhibit NR expression are at present tested in animal models of APAP toxicity or cholestasis. Some NR ligands have also been used in human cholestatic liver disease, but studies on the efficacy in DILI are lacking. This review describes possible future options for the treatment of DILI.
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