期刊
JOURNAL OF INFECTION
卷 55, 期 5, 页码 408-413出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2007.07.012
关键词
teicoplanin; therapeutic drug monitoring; trough levels; osteomyelitis; musculoskeletal infection
Objectives: Previously published data suggest that a trough serum teicoplanin level of >= 20 mg/l is predictive of improved outcomes in serious staphylococcal infection. We investigated how dose regimen and patient characteristics impact on trough teicoplanin levels in patients with musculoskeletal infection, in order to help standardise teicoplanin use. Methods: We prospectively collected data for 141 clinically stable adults with bone and joint infection treated as outpatients with teicoplanin. Patients with end stage renal failure were excluded. Results: The most frequently used teicoplanin dose regimens were 400 mg or 600 mg iv once daily. Trough levels were available for 78% of episodes, of which 51% were >= 20 mg/l. Unsurprisingly, a level of >= 20 mg/l occurred more often with a dose of 600 mg than with lower doses (p = 0.005). There was no significant relationship between teicoplanin level and age, body weight or creatinine clearance, but mate gender was associated with tower trough levels than female gender (p = 0.03). Conclusions: These data suggest that teicoplanin Levels of >= 20 mg/l for bone and joint infection in stable adult patients are best achieved with a daily dose of at least 600 mg. (c) 2007 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据