期刊
MAGNETIC RESONANCE IN CHEMISTRY
卷 45, 期 11, 页码 989-992出版社
WILEY
DOI: 10.1002/mrc.2087
关键词
nuclear magnetic resonance; micro channeled cell for synthesis monitoring; B-11; intermediate; oxime ether; Et3B; radical reaction
Direct observation of the unstable intermediate in the radical addition reaction of the oxime ether 1 mediated by triethylborane (Et3B) is described using H-1 and B-11 micro channeled cell for synthesis monitoring (MICCS), which was recently developed as an interfacing microchip for NMR. It was possible that the signal of the intermediate was observed as a result of using MICCS technique with a standard NMR instrument. This result supports the structure of the intermediate analyzed by diffusion-ordered spectroscopy (DOSY) NMR method in a previous paper. The procedure of micro channeled cell for synthesis monitoring-nuclear magnetic resonance (MICCS-NMR) was much easier than that of DOSY method. It was proven that it could be applied to the reaction in an anhydrous condition. Copyright (c) 2007 John Wiley & Sons, Ltd.
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