期刊
NATURE GENETICS
卷 39, 期 11, 页码 1329-1337出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2007.17
关键词
-
资金
- Arthritis Research UK [17552] Funding Source: Medline
- Cancer Research UK [A4994] Funding Source: Medline
- Medical Research Council [G90/106, G0501942, G19/9, G0701003, G0000934, G0800759, G0600329, G9810900, G0600705] Funding Source: Medline
- Multiple Sclerosis Society [730] Funding Source: Medline
- NCRR NIH HHS [UL1 RR024148, M01 RR000425] Funding Source: Medline
- NIAMS NIH HHS [R01 AR048465, R01 AR046208] Funding Source: Medline
- Wellcome Trust [081682, 090532, 076113, 057097, 089989] Funding Source: Medline
- Chief Scientist Office [CZB/4/540] Funding Source: Medline
- Chief Scientist Office [CZB/4/540] Funding Source: researchfish
- Medical Research Council [G0000934, G90/106, G0600705, G0600329, G0501942, G19/9, G9810900] Funding Source: researchfish
- MRC [G90/106, G0501942, G0000934, G0600329, G19/9, G0600705, G9810900] Funding Source: UKRI
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis ( AS), autoimmune thyroid disease (AITD), multiple sclerosis ( MS) and breast cancer ( BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major `seronegative' diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据