Synthesis, cytotoxicity and clastogenicity of novel α-aminophosphonic acids

alpha-Ethyl-N-(phosphonomethyl) glycine is synthesized and characterized by NMR and FAB spectroscopy. The cytotoxicity, clastogenic and antiproliferative effect of 3-ethyl-2-hydroxyl-2-oxo-1,4,2-oxazaphosphorinane, sodium salt of 3-ethyl-2-hydroxyl-2-oxo-1,4,2-oxazaphosphorinane, alpha-ethyl-alpha-N-(hydroxyethylamino) methylphosphonic acid, alpha-ethyl-N-(phosphonomethyl) glycine, alpha-ethyl-N-(phosphonomethyl) glycine isopropylammonium salt, glyphosate isopropylammonium salt are tested.