期刊
POULTRY SCIENCE
卷 86, 期 11, 页码 2322-2326出版社
POULTRY SCIENCE ASSOC INC
DOI: 10.3382/ps.2007-00238
关键词
chicken; mannan-binding lectin; mannan-binding lectin-associated serine protease 2; complement activation; complement factor 4 deposition
To investigate the ability of chicken mannan-binding lectin (cMBL) to work as a complement activator, a heterogeneous ELISA test was developed, in which the deposition of human complement factor 4 (C4) was used as a measure of complement activation ability. Serum from different experimental chicken lines was tested. The correlation between serum cMBL concentrations and human C4 deposition was high (correlation = 0.8549, P < 0.0001). There was no difference in C4 deposition among sera from the chicken lines when calculated as C4 deposition relative to the cMBL concentration.
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