期刊
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
卷 57, 期 5, 页码 767-774出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2007.04.012
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An alternative to currently marketed topical minoxidil solutions is desirable. Objective: To assess the efficacy and safety of a new 5% minoxidil topical formulation in a propylene glycol-free foam vehicle in men with androgenetic alopecia (AGA). Methods: This was a 16-week, double-blind, placebo-controlled trial of 5% minoxidil topical foam (MTF) in 352 men, 18 to 49 years old. At week 16, 143 subjects continued on an open-label phase to collect 52 weeks of safety information on 5% MTF. Results: At week 16 compared with baseline, there was a statistically significant increase in (1) hair counts in the 5% MTF group versus placebo (P <.0001) and (2) subjective assessment of improved hair loss condition (P <.0001) in the 5% MTF group versus placebo. The 5% MTF was well tolerated over a 52-week period. Limitations: There was no collection of efficacy data beyond 16 weeks. Conclusions: We believe that 5% MTF is a safe and effective treatment for men with AGA. (J Am Acad Dermatol 2007;57:767-74.)
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