期刊
EXPERIMENTAL PARASITOLOGY
卷 117, 期 3, 页码 229-235出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2007.06.001
关键词
trematode; schistosomiasis; expressed sequence tags; transcriptome; cDNA, complementary DNA; mRNA, messenger RNA; STS, sequence-tagged sites; ORESTES, Open Reading Frame Expressed Sequence Tags; RGMG, Minas Gerais Genome Network; CDD, Conserved Domain Database; KEGG, Kyoto Encyclopedia of Genes and Genomes; RNA, ribonucleic acid; DNA, deoxyribonucleic acid; SNP, single nucleotide polymorphism; MR4, Malaria Research and Reference Reagent Resource; SR3, Schistosome Related Reagent Repository; SAGE, Serial Analysis of Gene Expression
类别
资金
- FIC NIH HHS [R03 TW007358, D43 TW007012, 5D43TW007012-03, D43 TW007012-04, 5R03TW007358-02] Funding Source: Medline
Large scale EST sequencing projects have been carried out for Schistosoma mansoni and Schistosoma japonicum. This update will briefly review the most recent accomplishments in the area and discuss the use of EST data for the purposes of gene discovery, gene model development, genome annotation and SNP analysis. In addition, the use of ESTs for studying other features of the transcriptome such as splice site and transcription initiation variants will be discussed as well as approaches to assigning function to unknown transcripts. Although EST sequencing has contributed much for schistosome research, other data mining possibilities exist, including the identification of putative drug and vaccine targets. (C) 2007 Elsevier Inc. All rights reserved.
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