期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 9, 期 11, 页码 2027-2033出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2007.1642
关键词
-
资金
- NIA NIH HHS [2 PO1 AG 15885, 1 RO1 AG024413] Funding Source: Medline
Glutaredoxins (GRx) catalyze reversible protein glutathionylation. They are implicated in sulfhydryl homeostasis and regulation of redox signal transduction, controlling various cellular processes like DNA synthesis, defense against oxidative stress, apoptosis signaling, and DNA-binding of transcription factors. Two isoforms of GRx are well characterized in mammals: GRx1, the cytosolic form, and GRx2, the mitochondrial form. Here we report documentation of GRx1 in mitochondria, localized exclusively in the intermembrane space and segregated from GRx2, localized exclusively in the mitochondrial matrix. We hypothesize that GRx1 and GRx2 in their unique locations regulate different functions of the mitochondria via reversible S-glutathionylation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据