期刊
TRENDS IN IMMUNOLOGY
卷 28, 期 11, 页码 503-510出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2007.07.010
关键词
-
类别
资金
- NIAID NIH HHS [N01AI40045, AI40045] Funding Source: Medline
Dendritic cells (DCs), including Langerhans Cells (LCs), are probably among the earliest targets of HIV infection. Their localization in mucosal epithelia and in the T cell areas of lymphoid organs, as well as their crucial role in capturing antigens and initiating T cell responses, highlight their potential importance. Studies with cells in culture have addressed different outcomes of the HIV-DC interaction, which include: direct productive infection of DC; carriage of virus by DC to CD4(+) T cells; transfer of virus between DC and T cells at an infectious synapse; and immune evasion strategies of infected DC. Here we review the literature covering these areas, including current knowledge of underlying mechanisms or pathways.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据