期刊
INFLAMMATORY BOWEL DISEASES
卷 13, 期 11, 页码 1333-1338出版社
JOHN WILEY & SONS INC
DOI: 10.1002/ibd.20223
关键词
inflammatory bowel disease; Crohn's disease; ulcerative colitis; genotype; genetics
资金
- NIDDK NIH HHS [R01 DK056328, P01 DK046763, P30 DK063491-049004, R01 DK056328-07, P30 DK063491-019004, P30 DK063491-029004, P01 DK046763-14, DK56328, P30 DK063491, DK46763, P30 DK063491-039004, P01 DK046763-150001, P01 DK046763-140001] Funding Source: Medline
Background: inflammatory bowel disease (1131)) is a clinically and, likely, genetically heterogeneous group of disorders. A recent report suggests that genetic variations in the TNFSF15 gene contribute to the susceptibility of 1131) in both Japanese and Caucasian populations. The aim was to confirm the association between TNFSF15 high and low-risk haplotypes and 1131) in a Caucasian population. Methods: Five single-nucleotide polymorphisms (SNPs) that comprise the 2 common haplotypes were genotyped in 599 Caucasian patients with Crohn's disease (CD), 382 Caucasian patients with ulcerative colitis (UC), and 230 ethnically matched healthy controls, including both Jews and non-Jews. Results: The previously reported 'risk' haplotype was not associated with CD or UC (88.2% in CD cases versus 88.3% in controls, P = 0.96; 88.1% in UC cases versus 88.3% in controls, P = 0.78). We did, however, observe an increased frequency of the protective haplotype in non7Jewish controls for both CID and UC (38.8% CD cases versus 50% controls, P = 0.01; 37.3% UC cases versus 50% controls, P = 0.01) with no such effect observed in the Jewish samples. There was an interactive effect between ethnicity and the protective haplotype in CD (P = 0.04). Conclusions: We observed a protective haplotype, consisting of the minor alleles for all 5 markers, to have a higher frequency in the non-Jewish controls than in CD and UC. Of further interest, the haplotype frequency was in the opposite direction in our Jewish case-control panels (both CD and UC), leading us to conclude 1) that TNFSF15 is indeed an IBD susceptibility gene, and 2) the disease susceptibility is ethnic-specific.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据