4.6 Article

The transcription profile of the Bocavirus bovine parvovirus is unlike those of previously characterized Parvoviruses

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JOURNAL OF VIROLOGY
卷 81, 期 21, 页码 12080-12085

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AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00815-07

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  1. NCRR NIH HHS [P20 RR 016443, P20 RR016443] Funding Source: Medline
  2. NIAID NIH HHS [R01 AI046458, R01 AI 46458, R56 AI070723, R01 AI056310, R01 AI 21302, R56 AI 070723, R01 AI021302, R01 AI 56310] Funding Source: Medline

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The Bocavirus bovine parvovirus generated a single pre-mRNA from a promoter at its left-hand end; however, the pattern of its alternative polyadenyllation and splicing was different from that of other parvoviruses. A large left-hand-end open reading frame (ORF) encoded a nonstructural protein of approximately 95 kDa. An abundant, spliced, internally polyadenylated transcript encoded the viral NP1 protein from an ORF in the center of the genome. Transcripts encoding the capsid proteins were polyadenylated in the right-hand terminal palindrome. This is the first published transcription map of a member of the Bocavirus genus of the Parvovirinae.

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