Synthesis and anti-staphylococcal activity of new halogenated pyrroles related to pyrrolomycins F

The chemical synthesis of new halogenated pyrroles related to pyrrolomycins F is described and the anti-staphylococcal activity compared. The replacement of 4'-bromo atom of parent compounds with two chloro atoms at 3' and 5' position increase the antibacterial activity against a reference strain of S. aureus.