期刊
NEUROCHEMICAL RESEARCH
卷 32, 期 11, 页码 1940-1949出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-007-9389-7
关键词
anion channel; glial cell; cell proliferation; osmosensitive taurine release; ERK; JNK
Cell swelling is associated with the activation of an increase in the osmosensitive taurine release (OTR) rate, which serves to decrease cell volume as part of a process known as regulatory volume decrease. OTR, which is sensitive to many pharmacological agents including anion channel blockers and signalling pathway modulators, has also been suggested to play a role in cell cycle progression. At non-cytotoxic concentrations, the anion channel blocker NPPB (25 mu M), the extra-cellular signal-regulated kinase inhibitor PD98059 (50 mu M), and the c-Jun NH2-terminal kinase inhibitor SP 600125 (5 mu M) each decreased the OTR rate by >= 50%, decreased cell proliferation, and increased G0/G1 cell cycle arrest.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据