期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 389, 期 5, 页码 1525-1532出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-007-1543-1
关键词
FT-IR spectroscopy; fake drugs; malaria; chemical imaging; sors; turbid; artesunate
资金
- Wellcome Trust Funding Source: Medline
- Engineering and Physical Sciences Research Council [EP/C532678/1] Funding Source: researchfish
In support of the efforts to combat the illegal sale and distribution of counterfeit anti-malarial drugs, we evaluated a new analytical approach for the characterization and fast screening of fake and genuine artesunate tablets using a combination of Raman spectroscopy, Spatially Offset Raman Spectroscopy (SORS) and Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) imaging. Vibrational spectroscopy provided chemically specific information on the composition of the tablets; the complementary nature of Raman scattering and FTIR imaging allowed the characterization of both the overall and surface composition of the tablets. The depth-resolving power of the SORS approach provided chemically specific information on the overall composition of the tablets, non-invasively, through a variety of packaging types. Spatial imaging of the tablet surface (using ATR-FTIR) identified the location of domains of excipients and active ingredients with high sensitivity and enhanced spatial resolution. The advantages provided by a combination of SORS and ATR-FTIR imaging in this context confirm its potential for inclusion in the analytical protocol for forensic investigation of counterfeit medicines.
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