期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 26, 期 9, 页码 2627-2632出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1460-9568.2007.05872.x
关键词
conditioned taste aversion; gustatory neophobia; insular cortex; latent inhibition; rat
资金
- NIDCD NIH HHS [R01 DC004341, R56 DC006456, DC04341, DC06456] Funding Source: Medline
The present study tested the hypothesis that lesions of the insular cortex of the rat retard the acquisition of conditioned taste aversions (CTAs) because of an impairment in the detection of the novelty of taste stimuli. Demonstrating the expected latent inhibition effect, nonlesioned control subjects acquired CTAs more rapidly when the conditioned stimulus (0.15% sodium saccharin) was novel rather than familiar (achieved by pre-exposure to the to-be-conditioned taste cue). However, rats with insular cortex lesions acquired taste aversions at the same slow rate regardless of whether the saccharin was novel or familiar. The pattern of behavioural deficits obtained cannot be interpreted as disruptions of taste detection or stimulus intensity, but is consistent with the view that insular cortex lesions disrupt taste neophobia, a dysfunction that consequently retards CTA acquisition because of a latent inhibition-like effect.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据