期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 26, 期 5, 页码 1210-1215出版社
JOHN WILEY & SONS INC
DOI: 10.1002/jmri.21145
关键词
magnetic resonance imaging; safety; cDNA microarray; protein-gene expression; 3 T
Purpose: To evaluate the influence of magnetic resonance imaging (MRI) on gene expression in embryonic human lung fibroblasts (Hel 299). Materials and Methods: The cells were exposed to the static magnetic field and to a turbo spin-echo sequence of an MR scanner at 3.0 Tesla. An MR group (exposed) and a control group (sham-exposed) were set up using a special MR-compatible incubation system. The exposure time was two hours. Gene expression profiles were studied using a complementary deoxyribonucleic acid (cDNA) microarray containing 498 known genes involved in transcription, intracellular transport, structure/junction/adhesion or extracellular matrix, signaling, host defense, energetics, metabolism, cell shape, and death. Results: No changes in gene expression were found in either group (exposed or sham-exposed cells) at the end of a two-hour exposure for any of the 498 tested protein genes. Conclusion: The results suggest that MRI has no influence on protein-gene expression in eugenic human lung cells.
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