期刊
MINI-REVIEWS IN ORGANIC CHEMISTRY
卷 4, 期 4, 页码 317-329出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157019307782411699
关键词
fluorine-18; positron emission tomography (PET); labeling chemistry
In this short review we describe recent methods and novel trends for the introduction of fluorine-18 into molecules which in turn are intended to serve as imaging agents for the in vivo imaging modality positron emission tomography (PET). These F-18-labeling schemes are based on enzymatic fluorination, the use of ionic liquids, protic solvents acting as catalysts, application of click chemistry, thiol-reactive labeling agents for peptide and protein labeling and the most recent introduction of non-classical radiochemistry based on organo-phosphorous, organo-boron and organo-silicon radiochemistry. The latter approach for the first time introduced an F-18-chemistry characterized by high selectivity and unique efficiency making complicated work-up procedures obsolete.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据