期刊
EXPERIMENTAL PHYSIOLOGY
卷 92, 期 6, 页码 988-991出版社
BLACKWELL PUBLISHING
DOI: 10.1113/expphysiol.2006.036343
关键词
-
类别
The regulation of tissue perfusion is a major mechanism by which oxygen homeostasis is maintained. Hypoxia-inducible factor 1 (HIF-1) is a transcriptional regulator that mediates adaptive responses to reduced partial pressure of O-2 in all metazoan species. In mammals, HIF-1 promotes angiogenesis, arteriogenesis and vasculogenesis through the production of multiple angiogenic growth factors in ischaemic tissue and by cell-autonomous effects on endothelial cells and bone marrow-derived angiogenic cells. Administration of viral vectors encoding constitutively active forms of the HIF-1 alpha subunit results in increased tissue perfusion in animal models of ischaemic cardiovascular disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据