期刊
JOURNAL OF DENTAL RESEARCH
卷 86, 期 11, 页码 1120-1125出版社
INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R
DOI: 10.1177/154405910708601119
关键词
temporomandibular joint disorders; cohort studies; psychology; catechol O-methyltransferase; genetics
资金
- Intramural NIH HHS Funding Source: Medline
- NIAID NIH HHS [AR/AI-44564] Funding Source: Medline
- NIDCR NIH HHS [DE007333, DE07509] Funding Source: Medline
- NINDS NIH HHS [NS045685] Funding Source: Medline
Psychological characteristics potentially may be a cause or consequence of temporomandibular disorder (TMD). We hypothesized that psychological characteristics associated with pain sensitivity would influence risk of first-onset TMD, but the effect could be attributed to variation in the gene encoding catechol-O-methyltransferase (COMT). We undertook a prospective cohort study of healthy female volunteers aged 1834 yrs. At baseline, participants were genotyped, they completed psychological questionnaires, and underwent quantitative sensory testing to determine pain sensitivity. We followed 171 participants for up to three years, and 8.8% of them were diagnosed with first-onset TMD. Depression, perceived stress, and mood were associated with pain sensitivity and were predictive of 2- to 3-fold increases in risk of TMD (P < 0.05). However, the magnitude of increased TMD risk due to psychological factors remained unchanged after adjustment for the COMT haplotype. Psychological factors linked to pain sensitivity influenced TMD risk independently of the effects of the COMT haplotype on TMD risk.
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