期刊
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
卷 156, 期 1, 页码 74-79出版社
ELSEVIER
DOI: 10.1016/j.molbiopara.2007.07.002
关键词
malaria; Plasmodium vivax; Plasmodium cynomolgi; msp1; polymorphism; evolution
The Plasmodium MSP-1 is a promising malaria vaccine candidate. However, the highly polymorphic nature of the MSP-1 gene (msp1) presents a potential obstacle for effective vaccine development. To investigate the evolutionary history of msp1 polymorphism in P. vivax, we construct phylogenetic trees of insp1 from P. vivax and related monkey malaria parasite species. All P. vivax msp1 alleles cluster in the P vivax lineage and are not distributed among other species. Similarly, all P. cynomolgi msp] alleles cluster in the P. cynomolgi lineage. This suggests that, in contrast to presumed ancient origin of P falciparum insp1 polymorphism, the origin of P. vivax msp1 polymorphism is relatively recent. We observed positive selection in the P vivax lineage but not in P. cynomolgi. Also, positive selection acts on different regions of msp I in P. vivax and P. falciparum. This study shows that the evolutionary history of msp1 differs greatly among parasite lineages. (C) 2007 Elsevier B.V. All rights reserved.
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