期刊
SURVEY OF OPHTHALMOLOGY
卷 52, 期 -, 页码 S101-S104出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.survophthal.2007.08.002
关键词
extracellular matrix; intraocular pressure; primary open-angle glaucoma; trabecular meshwork; transforming growth factor-beta 2
Intraocular pressure, the most critical risk factor for primary open-angle glaucoma is generated in the trabecular meshwork outflow pathways, which provide resistance to aqueous humor outflow. The resistance is increased in primary open-angle glaucoma, and changes in the quality and amount of the extracellular matrix in the juxtacanalicular region of the trabecular meshwork appear to be causatively involved. The extracellular matrix changes are very likely under control of transforming growth factor-beta 2 (TGF-beta 2), which is found at high concentrations in the aqueous humor of patients with primary open-angle glaucoma. Additional factors are thrombospondin-1, which activates TGF-beta 2 in vivo, and connective tissue growth factor, which is an important downstream mediator of the effects of TGF-beta 2 on trabecular meshwork extracellular matrix turnover. In contrast, bone morphogenetic protein-7 (BMP-7) strongly antagonizes fibrogenic actions of TGF-beta 2 on human trabecular meshwork cells, indicating that a pharmacological modulation of BMP-7 signalling might be a promising strategy to treat primary open-angle glaucoma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据