期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 11, 期 6, 页码 1239-1250出版社
WILEY
DOI: 10.1111/j.1582-4934.2007.00127.x
关键词
caveolae; endocytosis; phosphorylation; Src; caveolin-1; actin cytoskeleton
资金
- NHLBI NIH HHS [HL 71628, P01 HL060678, R01 HL071626, HL 60678] Funding Source: Medline
Caveolae are flask-shaped plasma membrane invaginations that mediate endocytosis and transcytosis of plasma macromolecules, such as albumin, insulin and low-density lipoprotein (LDL), as well as certain viruses, bacteria and bacterial toxins. Caveolae-mediated transcytosis of macromolecules is critical for maintaining vascular homeostasis by regulating the oncotic pressure gradient and tissue delivery of drugs, vitamins, lipids and ions. Entrapment of cargo within caveolae induces activation of signalling cascades leading to caveolae fission and internalization. Activation of Src tyrosine kinase is an early and essential step that triggers detachment of loaded caveolae from the plasma membrane. In this review, we examine how Srcmediated phosphorylation regulates caveolae-mediated transport by orchestrating the localization and activity of essential proteins of the endocytic machinery to regulate caveolae formation and fission.
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