期刊
EUROPEAN JOURNAL OF CANCER
卷 43, 期 17, 页码 2487-2494出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2007.08.017
关键词
economics; cost and cost analysis; monoclonal antibodies; bevacizumab
类别
Background: Bevacizumab is a humanised monoclonal antibody, which has demonstrated significant activity in metastatic colorectal cancer. The aim of this study is to estimate the cost-effectiveness of adding bevacizumab to chemotherapy for patients with untreated metastatic colorectal cancer. Methods: A decision-analytic model was developed to estimate the lifetime costs and benefits of adding bevacizumab to irinotecan plus FU/LV (IFL) or 5-FU/LV alone. Effectiveness outcomes, health utilities and resource use data were derived from recent bevacizumab RCTs and from the literature. Results: Adding bevacizumab to IFL costs approximately (sic)62,857 per QALY gained. Adding bevacizumab to 5-FU/LV costs approximately (sic)88,436 per QALY gained. The acquisition cost of bevacizumab is a key determinant of its cost-effectiveness. The probability that bevacizumab has a cost-effectiveness ratio that is better than (sic)30,000 per QALY gained is close to zero. Conclusions: Given high acquisition costs in relation to clinical benefits, bevacizumab is unlikely to represent a cost-effective use of NHS resources. (c) 2007 Elsevier Ltd. All rights reserved.
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