期刊
ARCHIV DER PHARMAZIE
卷 340, 期 11, 页码 586-590出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.200700134
关键词
anti-inflammatory activity; carrageenan induced oedema; triazole
The reaction of acetic or propionic acid hydrazides with various aryl/alkyl isothiocyanates gave thiosemicarbazides which furnished the 1,2,4-triazoles by alkali cyclization. The 4-aryl/allcyl-5-(1phenoxyethyl)-3-[N-(substituted)acetamido]thio-4H-1,2,4-triazole derivatives were synthesized by reactinc the triazoles with 2-chloro-N-(substituted)acetamide. The chemical structures of the compounds were elucidated by IR, H-1-NMR, FAB(+)-MS spectral data and elemental analysis. In the pharmacological studies, anti-inflammatory activities of these compounds have been screened and significant activities were observed.
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