期刊
BIOLOGICAL CHEMISTRY
卷 388, 期 11, 页码 1131-1140出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2007.150
关键词
cancer; cathepsin B; cysteine cathepsin; glycosaminoglycan
资金
- NCI NIH HHS [CA36481, CA56586, P30 CA22453] Funding Source: Medline
- NCRR NIH HHS [U54 RR020843] Funding Source: Medline
- NIEHS NIH HHS [P30 ES06639] Funding Source: Medline
Cysteine cathepsins play a fundamental role in tumor growth, invasion and migration, angiogenesis, and the metastatic cascade. Evidence of their overexpression in a wide array of human tumors has been well documented. Cysteine cathepsins seem to have a characteristic location-function relationship that leads to non-traditional roles such as those in development and pathology. For example, during tumor development, some cysteine cathepsins are found not just within lysosomes, but are also redistributed into presumptive exocytic vesicles at the cell periphery, resulting in their secretion. This altered localization contributes to non-lysosomal functions that have been linked to malignant progression. Mechanisms for altered localization are not well understood, but do include the interaction of cysteine cathepsins with binding partners that modulate intracellular trafficking and association with specific regions on the cell surface.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据