期刊
AMERICAN JOURNAL OF MEDICINE
卷 120, 期 11, 页码 S1-S21出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjmed.2007.09.001
关键词
antidiuretic hormone; aquaretics; hypo-osmolality; natriuresis; syndrome of inappropriate antidiuretic hormone secretion; vasopressin
Although hyponatremia is a common, usually mild, and relatively asymptomatic disorder of electrolytes, acute severe hyponatremia can cause substantial morbidity and mortality, particularly in patients with concomitant disease. In addition, overly rapid correction of chronic hyponatremia can cause severe neurologic deficits and death, and optimal treatment strategies for such cases are not established. An expert panel assessed the potential contributions of aquaretic nonpeptide small-molecule arginine vasopressin receptor ( AVPR) antagonists to hyponatremia therapies. This review presents their conclusions, including identification of appropriate treatment populations and possible future indications for aquaretic AVPR antagonists. (C) 2007 Elsevier Inc. All rights reserved.
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