期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 128, 期 5, 页码 759-766出版社
AMER SOC CLINICAL PATHOLOGY
DOI: 10.1309/7FXVRMXF58PVRJUH
关键词
breast; lymphangiogenesis; growth factor; breast cancer; metastasis; immunohistochemistry
类别
We assessed the expression of vascular endothelial growth factors (VEGF-C and VEGF-D) in breast cancer cells and the density of lymph vessels and VEGF receptor-3 (VEGFR-3)-positive vessels in and around the tumor in invasive lobular breast cancer We found significant correlation between peritumoral lymph vessel density and presence of lymph node metastases (P =.001) and the number of metastatic lymph nodes (P <.001). A significant correlation was detected between tumor cell VEGF-D expression and lymph node status (P =.001) and density of lymphatic vessel endothelial receptor (LYVE)-l-positive vessels (P =.035). VEGFR-3+/VEGF-D+ and VEGFR-3+/VEGF-C+ tumors had a significantly higher number of metastatic lymph nodes than tumors with other staining patterns (P <. 001). Tumors positive for neither VEGF-D nor VEGFR-3 had a lower density of LYVE-1 + vessels than tumors with other staining patterns (P =.033). Our results indicate that peritumoral lymph vessel density is associated with lymph node metastases in invasive lobular breast cancer and that invasive lobular cancer producing VEGF-D, surrounded by VEGFR-3+ vessels, has a significantly higher peritumoral lymph vessel density and a higher number of metastatic lymph nodes.
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