期刊
DIABETES OBESITY & METABOLISM
卷 9, 期 6, 页码 813-839出版社
WILEY
DOI: 10.1111/j.1463-1326.2007.00692.x
关键词
obesity; overweight; antioxidant; oxidative stress; exercise; dietary
资金
- NCCIH NIH HHS [K30-AT-00060] Funding Source: Medline
Purpose: Obesity may be a state of chronic oxidative stress. Oxidative stress may be the mechanism underlying the development of co-morbidities in obesity. This review provides a summary of the available evidence regarding systemic oxidative stress in young, older and clinical obese populations. Methods:Medline was searched for all available articles published between 1975 and 2006 that evaluated oxidative stress biomarkers in resting conditions or following various interventions in overweight and obese humans. Results: Obesity elevates oxidative stress in young, old and clinical populations as shown by elevations in lipid peroxidation (malondialdehyde, hydroperoxides, 4-hydroxynonenal, isoprostanes, conjugated dienes) or protein oxidation (8-hydroxy-deoxyguanosine). Lipid peroxidation is associated with several indices of adiposity and a low systemic antioxidant defence (i.e. antioxidant enzymes, tissue dietary antioxidants, glutathione). Oxidative stress may be exacerbated with acute exercise, advancing age or co-existing clinical conditions and may be corrected by improving antioxidant defences through fat volume reduction via surgery, pharmacological agents, exercise and/or dietary modification. Conclusion: Oxidative stress is related to chronic disease in obesity, but is reversible with one or more interventions described above.
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