期刊
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
卷 37, 期 -, 页码 31-35出版社
WILEY
DOI: 10.1111/ijlh.12349
关键词
Polyphosphate; platelets; coagulation; thrombosis; hemostasis
类别
资金
- National Heart Lung and Blood Institute of the NIH [R01 HL047014]
While we have understood the basic outline of the enzymes and reactions that make up the traditional blood coagulation cascade for many years, recently our appreciation of the complexity of these interactions has greatly increased. This has resulted in unofficial revisions' of the coagulation cascade to include new amplification pathways and connections between the standard coagulation cascade enzymes, as well as the identification of extensive connections between the immune system and the coagulation cascade. The discovery that polyphosphate is stored in platelet dense granules and is secreted during platelet activation has resulted in a recent burst of interest in the role of this ancient molecule in human biology. Here we review the increasingly complex role of platelet polyphosphate in hemostasis, thrombosis, and inflammation that has been uncovered in recent years, as well as novel therapeutics centered on modulating polyphosphate's roles in coagulation and inflammation.
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