期刊
JOURNAL OF NEUROCHEMISTRY
卷 103, 期 -, 页码 39-46出版社
WILEY
DOI: 10.1111/j.1471-4159.2007.04710.x
关键词
GD3 synthase-knockout mouse; glycosphingolipid; lipid raft; proliferation; proteoglycan; Ras-mitogen-activated protein kinase pathway
资金
- NIA NIH HHS [AG027199] Funding Source: Medline
- NINDS NIH HHS [NS26994, NS11853] Funding Source: Medline
The mammalian CNS is organized by a variety of cells, such as neurons and glia, which are generated from neural stem cells (NSCs), undifferentiated neural cells characterized by their high proliferative potential while retaining their capacity for self- renewal and multipotency. Various signals from the environment, such as the 'niche,' modulate the fate of NSCs in their ability for self-renewal, proliferation, differentiation, and survival. There is increasing evidence that glycoconjugates, including proteoglycans, glycoproteins, and glycolipids, which are part of the plasma membrane glycocalyx network, are involved in mediation of these signals. In the present review, we discuss the roles of glycoconjugates in regulating the fate of NSCs and in supporting the underlying signal transduction mechanisms.
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