期刊
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 42, 期 6, 页码 481-515出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409230701751611
关键词
glycans; carbohydrates; glycosylation; inhibitors; therapeutics
资金
- NCI NIH HHS [CA112278, CA119801, CA91290, CA46462] Funding Source: Medline
- NINDS NIH HHS [NS057066, NS053595] Funding Source: Medline
Glycans, the carbohydrate chains of glycoproteins, proteoglycans, and glycolipids, represent a relatively unexploited area for drug development compared with other macromolecules. This review describes the major classes of glycans synthesized by animal cells, their mode of assembly, and available inhibitors for blocking their blosynthesis and function. Many of these agents have proven useful for studying the biological activities of glycans in isolated cells, during embryological development, and in physiology. Some are being used to develop drugs for treating metabolic disorders, cancer, and infection, suggesting that glycans are excellent targets for future drug development.
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