期刊
ADVANCED MATERIALS
卷 19, 期 21, 页码 3579-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200701183
关键词
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Superparamagnetic Fe3O4 nanoparticles (NPs) are engineered to reversibly self-assemble in response to antagonistic enzyme inputs. Tyrosine kinase activity directs substrate-NPs and SH2 domain-NPs to coalesce via polyvalent SH2- phosphopeptide binding. Phosphatase antagonizes this process and directs NP dispersion. By coupling assembly to substrate phosphorylation, the kinase activity is imaged via quantitative T2 relaxation changes in MRI.
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