Batzelladine alkaloids from the caribbean sponge Monanchora unguifera and the significant activities against HIV-1 and AIDS opportunistic infectious pathogens

Five new polycyclic guanidine alkaloids, 16 beta-hydroxycrambescidin 359 (1), batzelladines K, L, M, and N (2-5), along with the previously reported ptilomycalin A ( 6), crambescidine 800 ( 7), batzelladine C ( 8), and dehydrobatzelladine C ( 9), were isolated from the Jamaican sponge Monanchora unguifera. Their structures were assigned on the basis of detailed analysis of 1D and 2D NMR, and mass spectral data. Their activities against cancer cell lines, protozoa, HIV-1 and AIDS opportunistic infectious pathogens (AIDS-OIs) including Mtb were evaluated. (c) 2007 Published by Elsevier Ltd.