期刊
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
卷 37, 期 -, 页码 92-98出版社
WILEY
DOI: 10.1111/ijlh.12358
关键词
Hepcidin; ferroportin; iron; anemia; iron overload
类别
资金
- NIDDK NIH HHS [R01 DK107309] Funding Source: Medline
Hepatic hormone hepcidin is a principal regulator of iron homeostasis and a pathogenic factor in common iron disorders. Hepcidin deficiency causes iron overload in hereditary hemochromatosis and iron-loading anemias, whereas hepcidin excess causes or contributes to the development of iron-restricted anemia in inflammatory diseases, infections, some cancers, and chronic kidney disease. Because of this, hepcidin may become a useful tool for diagnosis and management of iron disorders. Furthermore, a number of strategies that target hepcidin, its receptor, and its regulators are under development as novel therapeutic approaches for diseases associated with iron dysregulation.
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