4.8 Article

Gradual changes in hippocampal activity support remembering the order of events

期刊

NEURON
卷 56, 期 3, 页码 530-540

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CELL PRESS
DOI: 10.1016/j.neuron.2007.08.017

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资金

  1. NIMH NIH HHS [MH068982, R01 MH051570, F32 MH068982, MH051570, P50 MH071702, P50 MH071702-020002] Funding Source: Medline

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The hippocampus is thought to contribute to episodic memory in part by binding stimuli to their spatiotemporal context. The present study examined how hippocampal neuronal populations encode spatial and temporal context as rats performed a task in which they were required to remember the order of trial-unique sequences of odors. The results suggest that a gradual change in the pattern of hippocampal activity served as a temporal context for odor-sampling events and was important for successful subsequent memory of the order of those odors.

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