期刊
VIROLOGY
卷 368, 期 1, 页码 1-6出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2007.06.022
关键词
HIV-1; envelope; rac; fusion
类别
资金
- NCRR NIH HHS [M01 RR000722, 5-M01-RR-00722] Funding Source: Medline
- NIAID NIH HHS [U01 AI035042, AI24745, R01 AI024745-18, U01-AI-35042, R01 AI024745] Funding Source: Medline
A virus-dependent fusion assay was utilized to examine the activity of a panel of HIV-1, -2, and SIV isolates of distinct coreceptor phenotypes. This assay allowed identification of entry inhibitors, and characterization of an antagonist of a Rac guanine nucleotide exchange factor, as an inhibitor of HIV-mediated fusion. (C) 2007 Elsevier Inc. All rights reserved.
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