期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 59, 期 13, 页码 1319-1328出版社
ELSEVIER
DOI: 10.1016/j.addr.2007.08.011
关键词
microengineering; adherens junction; cell-matrix adhesion; photolithography
资金
- NHLBI NIH HHS [R01 HL073305, R01 HL073305-05A1] Funding Source: Medline
- NIAMS NIH HHS [P30 AR050950-020002, P30 AR050950] Funding Source: Medline
- NIBIB NIH HHS [R01 EB000262-06, R01 EB000262-09, R01 EB000262] Funding Source: Medline
Engineering artificial tissue constructs requires the appropriate spatial arrangement of cells within scaffolds. The introduction of microengineering tools to the biological community has provided a valuable set of techniques to manipulate the cellular environment, and to examine how cell structure affects cellular function. Using micropatterning techniques, investigators have found that the geometric presentation of cell-matrix adhesions are important regulators of various cell behaviors including cell growth, proliferation, differentiation, polarity and migration. Furthermore, the presence of neighboring cells in multicellular aggregates has a significant impact on the proliferative and differentiated state of cells. Using microengineering tools, it will now be possible to manipulate the various environmental factors for practical applications such as engineering tissue constructs with greater control over the physical structure and spatial arrangement of cells within their surrounding microenvironment. Published by Elsevier B.V.
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