期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 59, 期 13, 页码 1340-1350出版社
ELSEVIER
DOI: 10.1016/j.addr.2007.08.012
关键词
therapeutic neovascularization; angiogenesis; growth factor; temporal and spatial; quantitative; delivery system
资金
- NHLBI NIH HHS [R01 HL 069957, R01 HL069957-02, R01 HL069957-01A2, R01 HL069957-03, R01 HL069957-04, R01 HL069957] Funding Source: Medline
- NIDCR NIH HHS [R37 DE013033-10, R01 DE013349-03, R01 DE013349-06, R01 DE013349-05, R37 DE013033, R37 DE013033-07, R01 DE013349-02, R01 DE013349, R37 DE013033-09, R01 DE013349-04S1, R01 DE013349-03S1, R01 DE013349-07, R37 DE013033-08, R37 DE013033-06A1, R01 DE013349-01, R01 DE013349-04] Funding Source: Medline
Many of the qualitative roles of growth factors involved in neovascularization have been delineated, but it is unclear yet from an engineering perspective how to use these factors as therapies. We propose that an approach that integrates quantitative spatiotemporal measurements of growth factor signaling using 3-D in vitro and in vivo models, mathematic modeling of factor tissue distribution, and new delivery technologies may provide an opportunity to engineer neovascularization on demand. (C) 2007 Elsevier B.V. All rights reserved.
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