期刊
VIROLOGY
卷 368, 期 1, 页码 91-101出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2007.06.023
关键词
hMPV; airway epithelial cells; chemokines; inflammation; transcription factors
类别
资金
- NIAID NIH HHS [N01 AI030039, P01 AI062885, P01 AI062885-030003, T32 AI007536, T32 AI07536] Funding Source: Medline
- PHS HHS [P01 062885, 06676] Funding Source: Medline
Human metapneumovirus (hMPV) is a major cause of lower respiratory tract infections (LRTIs) in infants, elderly and immunocompromised patients. In this study, we show that hMPV can infect in a similar manner epithelial cells representative of different tracts of the airways. hMPV-induced expression of chemokines IL-8 and RANTES in primary small alveolar epithelial cells (SAE) and in a human alveolar type II-like epithelial cell line (A549) was similar, suggesting that A549 cells can be used as a model to study lower airway epithelial cell responses to hMPV infection. A549 secreted a variety of CXC and CC chemokines, cytokines and type I interferons, following hMPV infection. hMPV was also a strong inducer of transcription factors belonging to nuclear factor (NF)-kappa B, interferon regulatory factors (IRFs) and signal transducers and activators of transcription (STATs) families, which are known to orchestrate the expression of inflammatory and immunomodulatory mediators. (C) 2007 Elsevier Inc. All rights reserved.
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