Highly enantioselective synthesis of chiral allylic alcohols by asymmetric addition of novel mixed reagents of trialkenylbismuthines/dialkylzincs to aldehydes

A novel mixture of reagents of trialkenylbismuthines/dialkylzines was developed and applied toward the synthesis of chiral allylic alcohols. The chiral beta-amino alcohols catalyzed addition of the mixed reagents of trialkenylbismuthines/dialkylzincs to aldehydes gave enantiomerically enriched allylic alcohols with up to 97% ee. (c) 2007 Elsevier Ltd. All rights reserved.