期刊
FEBS LETTERS
卷 581, 期 27, 页码 5327-5331出版社
WILEY
DOI: 10.1016/j.febslet.2007.10.019
关键词
melanopsin; OPN4; pineal gland
资金
- Grants-in-Aid for Scientific Research [19107002] Funding Source: KAKEN
Melanopsin is a vertebrate non-visual opsin and functions as a circadian photoreceptor in mammalian retinas. Here we found the expression of two kinds of melanopsin genes in the chicken pineal gland and identified the presence of five isoforms derived from these two genes. Reconstitution of the recombinant proteins with 11-cis-retinal revealed that at least two of these melanopsin protein isoforms can function as blue-sensitive photopigments with absorption maxima at 476-484 nm. These values are consistent with maximal sensitivities of action spectra determined from the physiological and behavioral studies on mammalian melanopsins. The melanopsin isoforms found in this study may function as pineal circadian photoreceptors. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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