期刊
FEBS LETTERS
卷 581, 期 27, 页码 5185-5190出版社
WILEY
DOI: 10.1016/j.febslet.2007.10.005
关键词
Fas/CD95; apoptosis; caspases; cathepsin; cell death; cathepsin B
The potential role of cysteine cathepsins, especially cathepsin B, in Fas/CD95-induced apoptosis was investigated using wild-type and cathepsin B-deficient primary skin fibroblasts. Apoptosis was induced with an anti-Fas/CD95 antibody in the presence of cycloheximide and no difference was observed between the two genotypes. First cells with damaged mitochondria were observed similar to 3 h post apoptosis induction and their number was significantly increased after 11 h. In contrast, cells with damaged lysosomes were only seen after 15 h with no difference between the two genotypes. Moreover, Bid cleavage was found to be diminished in cathepsin B-deficient cells. These results suggest that cysteine cathepsins have no active role in Fas/CD95 apoptosis. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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