期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 129, 期 45, 页码 13798-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja0768136
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A catalytic method for the direct synthesis of carboxylic acid amides from amines and alpha-functionalized aldehydes is possible through the synergistic role of a N-heterocyclic carbene catalyst and imidazole, affording amides via activated carboxylates catalytically generated via an internal redox reaction of the aldehyde substrates. The use of imidazole or other N-heterocycles as an additive is essential to overcoming imine formation and serves as a uniquely reactive substrate for the generation of an acyl imidazolium intermediate that is converted to the final amide product.
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