期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 43, 期 10, 页码 1351-1371出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2007.08.011
关键词
mitochondria; proton leak; superoxide; hydroxynonenal; reactive oxygen species; lipid peroxidation; thennogenesis; insulin secretion; mild uncoupling; uncoupling protein
The physiological functions of the mitochondrial uncoupling proteins (UCP2 and UCP3) are still under debate. There is, however, ample evidence to indicate that, in contrast to UCP1, they are not crucial for nonshivering thermogenesis and do not catalyze the basal proton conductance of mitochondria. Rather, there is good evidence that they increase mitochondrial proton conductance when activated by superoxide, reactive oxygen species derivatives such as hydroxynonenal, and other alkenals or their analogues. This review critically examines the evidence of the different proposed mechanisms for UCPs functions, namely (a) to export fatty acid anions from mitochondria, (b) to regulate insulin secretion in pancreatic beta-cells, and (c) to cause mild uncoupling and so diminish mitochondrial superoxide production, hence protecting against oxidative damage. Beside, available scientific data on UCP4 and UCP5/BMCP1 will be reviewed. However, their physiological function has not yet been established. (C) 2007 Elsevier Inc. All rights reserved.
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