期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 22, 页码 6216-6219出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.09.018
关键词
CDK2; kinase inhibitors; pyrazolo[1,5-alpha]pyrimidine
A series of four bicyclic cores were prepared and evaluated as cyclin-dependent kinase-2 (CDK2) inhibitors. From the invitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior core for further elaboration in the identification of novel CDK2 inhibitors. (C) 2007 Elsevier Ltd. All rights reserved.
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